Protein Details: Aquaporin-2

Protein ID

ICDB_Pro_0326

Protein Name

Aquaporin-2

Gene Name

AQY2; AQY2-1

Organism

Saccharomyces cerevisiae (Bakers yeast)

Length

289 amino acids

AlphaFoldDB

AF-P0CD89-F1-model_v4.pdb

Function

Water channel required to facilitate the transport of water across membranes. Involved in freeze tolerance; osmotolerance and cell flocculation in liquid cultures. Is non-functional in most laboratory strains.

Sequence

MSNESNDLEKNISHLDPTGVDNAYIPPEQPETKHSRFNIDRDTLRNHFIAAVGEFCGTFMFLWCAYVICNVANHDVALTTEPEGSHPGQLIMIALGFGFSVMFSIWCFAGVSGGALNPAVSLSLCLARAISPARCVVMWFPQIIAGMAAGGAASAMTPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARYFPHYHWIYWIGPLLGAFLAWSVWQLLQILDYTTYVNAEKAAGQKKED

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1002/1097-0061(200007)16:10<897::aid-yea583>3.0.co;2-t; 10.1074/jbc.273.42.27565; 10.1073/pnas.98.3.1000; 10.1046/j.1432-1033.2001.01882.x; 10.1128/aem.68.12.5981-5989.2002; 10.1128/aem.70.6.3377-3382.2004